Ontology highlight
ABSTRACT:
SUBMITTER: Chang TW
PROVIDER: S-EPMC3249093 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Chang Ting-Wei TW Lin Yu-Ming YM Wang Chiu-Feng CF Liao You-Di YD
The Journal of biological chemistry 20111114 1
Antimicrobial peptides/proteins (AMPs) are important components of the host innate defense mechanisms. Here we demonstrate that the outer membrane lipoprotein, Lpp, of Enterobacteriaceae interacts with and promotes susceptibility to the bactericidal activities of AMPs. The oligomeric Lpp was specifically recognized by several cationic α-helical AMPs, including SMAP-29, CAP-18, and LL-37; AMP-mediated bactericidal activities were blocked by anti-Lpp antibody blocking. Blebbing of the outer membra ...[more]