Ontology highlight
ABSTRACT:
SUBMITTER: Nomura DK
PROVIDER: S-EPMC3249428 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Nomura Daniel K DK Morrison Bradley E BE Blankman Jacqueline L JL Long Jonathan Z JZ Kinsey Steven G SG Marcondes Maria Cecilia G MC Ward Anna M AM Hahn Yun Kyung YK Lichtman Aron H AH Conti Bruno B Cravatt Benjamin F BF
Science (New York, N.Y.) 20111020 6057
Phospholipase A(2)(PLA(2)) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here, we show that a distinct pathway exists in brain, where monoacylglycerol lipase (MAGL) hydrolyzes the endocannabinoid 2-arachidonoylglycerol to generate a major arachidonate precursor pool for neuroinflammatory prostaglandins. MAGL-disrupted animals show neuroprotection in a parkinsonian mouse model. These animals are spared the hemorrhag ...[more]