Ontology highlight
ABSTRACT:
SUBMITTER: Cho C
PROVIDER: S-EPMC3249483 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20111028 1
Dynein is a large cytoskeletal motor protein that belongs to the AAA+ (ATPases associated with diverse cellular activities) superfamily. While dynein has had a rich history of cellular research, its molecular mechanism of motility remains poorly understood. Here we describe recent X-ray crystallographic studies that reveal the architecture of dynein's catalytic ring, mechanical linker element, and microtubule binding domain. This structural information has given rise to new hypotheses on how the ...[more]