Noninvasive assessment of localized inflammatory responses.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC3249500 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Noninvasive assessment of localized inflammatory responses.
Zhou Jun J Tsai Yi-Ting YT Weng Hong H Tang Liping L
Free radical biology & medicine 20111029 1
Inflammatory diseases are associated with the accumulation of activated inflammatory cells, particularly polymorphonuclear neutrophils (PMNs), which release reactive oxygen species (ROS) to eradicate foreign bodies and microorganisms. To assess the location and extent of localized inflammatory responses, L-012, a highly sensitive chemiluminescent probe, was employed to noninvasively monitor the production of ROS. We found that L-012-associated chemiluminescence imaging can be used to identify an ...[more]
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