Ontology highlight
ABSTRACT:
SUBMITTER: Mamoor S
PROVIDER: S-EPMC3249505 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Mamoor Shahan S Onder Zeynep Z Karanam Balasubramanyam B Kwak Kihyuck K Bordeaux Jennifer J Crosby Lauren L Roden Richard B S RB Moroianu Junona J
Virology 20111206 2
In this study we examined the transport signals contributing to HPV16 L2 nucleocytoplasmic traffic using confocal microscopy analysis of enhanced green fluorescent protein-L2 (EGFP-L2) fusions expressed in HeLa cells. We confirmed that both nuclear localization signals (NLSs), the nNLS (1MRHKRSAKRTKR12) and cNLS (456RKRRKR461), previously characterized in vitro (Darshan et al., 2004), function independently in vivo. We discovered that a middle region rich in arginine residues (296SRRTGIRYSRIGNKQ ...[more]