Ontology highlight
ABSTRACT:
SUBMITTER: Siwiak M
PROVIDER: S-EPMC3249538 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Siwiak Marian M Edelman Aleksander A Zielenkiewicz Piotr P
Journal of molecular modeling 20110401 1
Cystic fibrosis (CF), the most common lethal genetic disease among Caucasians, is caused by mutations in cystic fibrosis transmembrane conductance regulator (CFTR). CFTR's main role is to transport chloride ions across epithelial cell membranes. It also regulates many cell functions. However, the exact role of CFTR in cellular processes is not yet fully understood. It is recognized that a key factor in CFTR-related regulation is its phosphorylation state. The important kinases regulating CFTR ar ...[more]