Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC3250054 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Li Feng F Lu Jie J Ma Xiaochao X
Drug metabolism and disposition: the biological fate of chemicals 20110927 1
The combination of lopinavir (LPV) and ritonavir (RTV) is one of the preferred regimens for the treatment of HIV infection with confirmed efficacy and relatively low toxicity. LPV alone suffers the poor bioavailability due to its rapid and extensive metabolism. RTV boosts the plasma concentration of LPV by suppressing its metabolism and thus increasing LPV efficacy. In the current study, we found that RTV also inhibits LPV bioactivation. LPV bioactivation was investigated in human liver microsom ...[more]