Ontology highlight
ABSTRACT:
SUBMITTER: Dalli J
PROVIDER: S-EPMC3250241 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Dalli Jesmond J Jones Carla P CP Cavalcanti Danielle M DM Farsky Sandra H SH Perretti Mauro M Rankin Sara M SM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110928 1
Under homeostatic conditions, a proportion of senescent CXCR4(hi) neutrophils home from the circulation back to the bone marrow, where they are phagocytosed by bone marrow macrophages. In this study, we have identified an unexpected role for the anti-inflammatory molecule annexin A1 (AnxA1) as a critical regulator of this process. We first observed that AnxA1(-/-) mice have significantly increased neutrophil numbers in their bone marrow while having normal levels of GM and G colony-forming units ...[more]