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Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.

ABSTRACT: Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination.

SUBMITTER: Huang JK

PROVIDER: S-EPMC3250284 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.

Huang Jeffrey K JK Fancy Stephen P J SP Zhao Chao C Rowitch David H DH Ffrench-Constant Charles C Franklin Robin J M RJ

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20111001 4

Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelina ...[more]

PMID: 21904791

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