Ontology highlight
ABSTRACT:
SUBMITTER: Lando D
PROVIDER: S-EPMC3250473 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lando David D Balmer Jenny J Laue Ernest D ED Kouzarides Tony T
PloS one 20120103 1
Post-translational modification of histone proteins are known to play an important role in regulating chromatin structure. In an effort to find additional histone modifications we set out to screen enzymes of the 2-oxoglutarate and Fe(II)-dependent (2-OG-Fe(II)) dioxygenase family for activity towards histones. Here we show that the Schizosaccharomyces pombe 2-OG-Fe(II) dioxygenase domain containing protein-2 (Ofd2) is a histone H2A dioxygenase enzyme. Using a combination of peptide screening an ...[more]