Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans.
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ABSTRACT:
SUBMITTER: Garten RJ
PROVIDER: S-EPMC3250984 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans.
Garten Rebecca J RJ Davis C Todd CT Russell Colin A CA Shu Bo B Lindstrom Stephen S Balish Amanda A Sessions Wendy M WM Xu Xiyan X Skepner Eugene E Deyde Varough V Okomo-Adhiambo Margaret M Gubareva Larisa L Barnes John J Smith Catherine B CB Emery Shannon L SL Hillman Michael J MJ Rivailler Pierre P Smagala James J de Graaf Miranda M Burke David F DF Fouchier Ron A M RA Pappas Claudia C Alpuche-Aranda Celia M CM López-Gatell Hugo H Olivera Hiram H López Irma I Myers Christopher A CA Faix Dennis D Blair Patrick J PJ Yu Cindy C Keene Kimberly M KM Dotson P David PD Boxrud David D Sambol Anthony R AR Abid Syed H SH St George Kirsten K Bannerman Tammy T Moore Amanda L AL Stringer David J DJ Blevins Patricia P Demmler-Harrison Gail J GJ Ginsberg Michele M Kriner Paula P Waterman Steve S Smole Sandra S Guevara Hugo F HF Belongia Edward A EA Clark Patricia A PA Beatrice Sara T ST Donis Ruben R Katz Jacqueline J Finelli Lyn L Bridges Carolyn B CB Shaw Michael M Jernigan Daniel B DB Uyeki Timothy M TM Smith Derek J DJ Klimov Alexander I AI Cox Nancy J NJ
Science (New York, N.Y.) 20090522 5937
Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecu ...[more]
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