Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3251012 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Wang Lan L Gural Alexander A Sun Xiao-Jian XJ Zhao Xinyang X Perna Fabiana F Huang Gang G Hatlen Megan A MA Vu Ly L Liu Fan F Xu Haiming H Asai Takashi T Xu Hao H Deblasio Tony T Menendez Silvia S Voza Francesca F Jiang Yanwen Y Cole Philip A PA Zhang Jinsong J Melnick Ari A Roeder Robert G RG Nimer Stephen D SD
Science (New York, N.Y.) 20110714 6043
The chromosomal translocations found in acute myelogenous leukemia (AML) generate oncogenic fusion transcription factors with aberrant transcriptional regulatory properties. Although therapeutic targeting of most leukemia fusion proteins remains elusive, the posttranslational modifications that control their function could be targetable. We found that AML1-ETO, the fusion protein generated by the t(8;21) translocation, is acetylated by the transcriptional coactivator p300 in leukemia cells isola ...[more]