Ontology highlight
ABSTRACT:
SUBMITTER: Osawa T
PROVIDER: S-EPMC3251107 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Osawa Tsuyoshi T Muramatsu Masashi M Wang Feng F Tsuchida Rika R Kodama Tatsuhiko T Minami Takashi T Shibuya Masabumi M
Proceedings of the National Academy of Sciences of the United States of America 20111205 51
Histone demethylase JHDM1D (also known as KDM7A) modifies the level of methylation in histone and participates in epigenetic gene regulation; however, the role of JHDM1D in tumor progression is unknown. Here, we show that JHDM1D plays a tumor-suppressive role by regulating angiogenesis. Expression of JHDM1D was increased in mouse and human cancer cells under long-term nutrient starvation in vitro. Expression of JHDM1D mRNA was increased within avascular tumor tissue at the preangiogenic switch, ...[more]