Ontology highlight
ABSTRACT:
SUBMITTER: Galkin VE
PROVIDER: S-EPMC3251117 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Galkin Vitold E VE Orlova Albina A Kudryashov Dmitri S DS Solodukhin Alexander A Reisler Emil E Schröder Gunnar F GF Egelman Edward H EH
Proceedings of the National Academy of Sciences of the United States of America 20111207 51
Cofilin/ADF proteins play key roles in the dynamics of actin, one of the most abundant and highly conserved eukaryotic proteins. We used cryoelectron microscopy to generate a 9-Å resolution three-dimensional reconstruction of cofilin-decorated actin filaments, the highest resolution achieved for a complex of F-actin with an actin-binding protein. We show that the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observe ...[more]