Ontology highlight
ABSTRACT:
SUBMITTER: Gaudio E
PROVIDER: S-EPMC3251228 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Gaudio Eugenio E Spizzo Riccardo R Paduano Francesco F Luo Zhenghua Z Efanov Alexey A Palamarchuk Alexey A Leber Amanda S AS Kaou Mohamed M Zanesi Nicola N Bottoni Arianna A Costinean Stefan S Rassenti Laura Z LZ Nakamura Tatsuya T Kipps Thomas J TJ Aqeilan Rami I RI Pekarsky Yuri Y Trapasso Francesco F Croce Carlo M CM
Blood 20111107 1
The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias. TCL1 dysregulation in B cells is responsible for the development of an aggressive form of chronic lymphocytic leukemia (CLL), the most common human leukemia. We have investigated the mechanisms underlying the oncogenic functions of Tcl1 protein using a mass spectrometry approach and have identified Atm (ataxia ...[more]