Ontology highlight
ABSTRACT:
SUBMITTER: Johansson DX
PROVIDER: S-EPMC3251598 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Johansson Daniel X DX Ljungberg Karl K Kakoulidou Maria M Liljeström Peter P
PloS one 20120104 1
RNA-based vaccines represent an interesting immunization modality, but suffer from poor stability and a lack of efficient and clinically feasible delivery technologies. This study evaluates the immunogenic potential of naked in vitro transcribed Semliki Forest virus replicon RNA (RREP) delivered intradermally in combination with electroporation. Replicon-immunized mice showed a strong cellular and humoral response, contrary to mice immunized with regular mRNA. RREP-elicited induction of interfer ...[more]