Effect of novel synthetic evodiamine analogue on sexual behavior in male rats.
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ABSTRACT:
SUBMITTER: Vyawahare NS
PROVIDER: S-EPMC3251647 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
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Effect of novel synthetic evodiamine analogue on sexual behavior in male rats.
Vyawahare Neeraj S NS Hadambar Avinash A AA Chothe Aparna S AS Jalnapurkar Rajeshwar R RR Bhandare Amol M AM Kathiravan Muthu K MK
Journal of chemical biology 20111004 1
Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodia ...[more]
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