Ontology highlight
ABSTRACT:
SUBMITTER: Johann DJ
PROVIDER: S-EPMC3251958 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Johann Donald J DJ Wei Bih-Rong BR Prieto DaRue A DA Chan King C KC Ye Xiaying X Valera Vladimir A VA Simpson R Mark RM Rudnick Paul A PA Xiao Zhen Z Issaq Haleem J HJ Linehan W Marston WM Stein Stephen E SE Veenstra Timothy D TD Blonder Josip J
Analytical chemistry 20100301 5
A method that relies on subtractive tissue-directed shot-gun proteomics to identify tumor proteins in the blood of a patient newly diagnosed with cancer is described. To avoid analytical and statistical biases caused by physiologic variability of protein expression in the human population, this method was applied on clinical specimens obtained from a single patient diagnosed with nonmetastatic renal cell carcinoma (RCC). The proteomes extracted from tumor, normal adjacent tissue and preoperative ...[more]