Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC3252356 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20111221 3
Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the regulation of skeletal development and bone formation is poorly understood. Investigations of the Atf4(-/-);Col2a1-Atf4 mouse model, in which Atf4 is selectively overexpressed in chondrocytes in an Atf4-null background, demonstrate that chondrocyte-derived Atf4 regulates osteoge ...[more]