Insights into minor group rhinovirus uncoating: the X-ray structure of the HRV2 empty capsid.

ABSTRACT: Upon attachment to their respective receptor, human rhinoviruses (HRVs) are internalized into the host cell via different pathways but undergo similar structural changes. This ultimately results in the delivery of the viral RNA into the cytoplasm for replication. To improve our understanding of the conformational modifications associated with the release of the viral genome, we have determined the X-ray structure at 3.0 Å resolution of the end-stage of HRV2 uncoating, the empty capsid. The structure shows important conformational changes in the capsid protomer. In particular, a hinge movement around the hydrophobic pocket of VP1 allows a coordinated shift of VP2 and VP3. This overall displacement forces a reorganization of the inter-protomer interfaces, resulting in a particle expansion an

SUBMITTER: Garriga D 

PROVIDER: S-EPMC3252380 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature