Ontology highlight
ABSTRACT:
SUBMITTER: Bierut LJ
PROVIDER: S-EPMC3252425 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Bierut L J LJ Goate A M AM Breslau N N Johnson E O EO Bertelsen S S Fox L L Agrawal A A Bucholz K K KK Grucza R R Hesselbrock V V Kramer J J Kuperman S S Nurnberger J J Porjesz B B Saccone N L NL Schuckit M M Tischfield J J Wang J C JC Foroud T T Rice J P JP Edenberg H J HJ
Molecular psychiatry 20111004 4
A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. We genotyped and analyzed this variant in three large European and African-American case-control studies in which alcohol dependence was defined by the Diagnostic and Statistical Manual of Menta ...[more]