Ontology highlight
ABSTRACT:
SUBMITTER: Siberry GK
PROVIDER: S-EPMC3252429 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Siberry George K GK Warshaw Meredith G MG Williams Paige L PL Spector Stephen A SA Decker Michael D MD Jean-Philippe Patrick P Yogev Ram R Heckman Barbara E BE Manzella Adam A Roa Jhoanna J Nachman Sharon S Lujan-Zilbermann Jorge J
The Pediatric infectious disease journal 20120101 1
<h4>Background</h4>Human immunodeficiency virus (HIV)-infected children are at increased risk of meningococcal infection and poor response to quadrivalent meningococcal conjugate vaccine (MCV4), but MCV4 has not been studied in preadolescent HIV-infected children.<h4>Methods</h4>The P1065 trial enrolled 2- to 10-year-old HIV-infected children with CD4 ≥ 25% to receive MCV4 at entry and at week 24. Rates of response (≥ 4-fold increase in rabbit serum bactericidal antibody) against each meningococ ...[more]