Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC3252577 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Yang Fen F Sun Luyang L Li Qian Q Han Xiao X Lei Liandi L Zhang Hua H Shang Yongfeng Y
The EMBO journal 20111007 1
SET8 is implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell-cycle progression, and development. As such, it is predicted that SET8 might be involved in the development and progression of tumour. However, whether and how SET8 might be implicated in tumourigenesis is currently unknown. Here, we report that SET8 is physically associated with TWIST, a master regulator of epithelial-mesenchymal transition (EMT). We demonstrated that SET8 and TWIST are function ...[more]