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The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.

ABSTRACT: Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

SUBMITTER: Roper KA

PROVIDER: S-EPMC3252869 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.

Roper Kimberley A KA Lange Heiko H Polyzos Anastasios A Berry Malcolm B MB Baxendale Ian R IR Ley Steven V SV

Beilstein journal of organic chemistry 20111208

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification. ...[more]

PMID: 22238543

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