Ontology highlight
ABSTRACT:
SUBMITTER: Opalka SM
PROVIDER: S-EPMC3252872 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20111214
Herein, we demonstrate that a homogeneous catalyst can be prepared continuously via reaction with a packed-bed of a catalyst precursor. Specifically, we perform continuous proline catalyzed α-aminoxylations using a packed-bed of L-proline. The system relies on a multistep sequence in which an aldehyde and thiourea additive are passed through a column of solid proline, presumably forming a soluble oxazolidinone intermediate. This transports a catalytic amount of proline from the packed-bed into t ...[more]