Ontology highlight
ABSTRACT:
SUBMITTER: Hirota S
PROVIDER: S-EPMC3253036 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Hirota Shinya S Liu Qian Q Lee Hye Shin HS Hossain Mohammad G MG Lacy-Hulbert Adam A McCarty Joseph H JH
Development (Cambridge, England) 20111201 23
The mouse retina is vascularized after birth when angiogenic blood vessels grow and sprout along a pre-formed latticework of astrocytes. How astrocyte-derived cues control patterns of blood vessel growth and sprouting, however, remains enigmatic. Here, we have used molecular genetic strategies in mice to demonstrate that αvβ8 integrin expressed in astrocytes is essential for neovascularization of the developing retina. Selective ablation of αv or β8 integrin gene expression in astrocytes leads t ...[more]