Ontology highlight
ABSTRACT:
SUBMITTER: Morrison EA
PROVIDER: S-EPMC3253143 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Morrison Emma A EA DeKoster Gregory T GT Dutta Supratik S Vafabakhsh Reza R Clarkson Michael W MW Bahl Arjun A Kern Dorothee D Ha Taekjip T Henzler-Wildman Katherine A KA
Nature 20111218 7379
Small multidrug resistance transporters provide an ideal system to study the minimal requirements for active transport. EmrE is one such transporter in Escherichia coli. It exports a broad class of polyaromatic cation substrates, thus conferring resistance to drug compounds matching this chemical description. However, a great deal of controversy has surrounded the topology of the EmrE homodimer. Here we show that asymmetric antiparallel EmrE exchanges between inward- and outward-facing states th ...[more]