Genetic and environmental correlates of topiramate-induced cognitive impairment.
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ABSTRACT:
SUBMITTER: Cirulli ET
PROVIDER: S-EPMC3253145 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Genetic and environmental correlates of topiramate-induced cognitive impairment.
Cirulli Elizabeth T ET Urban Thomas J TJ Marino Susan E SE Linney Kristen N KN Birnbaum Angela K AK Depondt Chantal C Attix Deborah K DK Radtke Rodney A RA Goldstein David B DB
Epilepsia 20111116 1
Topiramate is an antiepileptic drug that has marked treatment-limiting side effects on specific aspects of cognitive performance in both patients and healthy volunteers. Because these severe side effects occur only in certain individuals, identifying genetic or environmental variables that influence cognitive response would be of great utility in determining whether to administer this drug to a patient. We gave an acute 100 mg oral dose of topiramate to 158 healthy volunteers and measured how th ...[more]
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