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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.


ABSTRACT: In this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic choriomeningitis virus and vaccinia virus in mice. We also show directly that cross-reactive T cells mediate protective heterologous immunity in mice. Subsets of T cell populations reactive with one epitope cross-reacted with either of several other epitopes encoded by the same or the heterologous virus. Human T cells specific to EBV-encoded BMLF1(280-288) could be cross-reactive with two influenza A virus or two other EBV epitopes. Mouse T cells specific to the vaccinia virus-encoded a11r(198-205) could be cross-reactive with three different lymphocytic choriomeningitis virus, one Pichinde virus, or one other vaccinia virus epitope. Patterns of cross-reactivity differed among individuals, reflecting the private specificities of the host's immune repertoire and divergence in the abilities of T cell populations to mediate protective immunity. Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines.

SUBMITTER: Cornberg M 

PROVIDER: S-EPMC3253758 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.

Cornberg Markus M   Clute Shalyn C SC   Watkin Levi B LB   Saccoccio Frances M FM   Kim Sung-Kwon SK   Naumov Yuri N YN   Brehm Michael A MA   Aslan Nuray N   Welsh Raymond M RM   Selin Liisa K LK  

Journal of immunology (Baltimore, Md. : 1950) 20100217 6


In this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic choriomeningitis virus and vaccinia virus in mice. We also show directly that cross-reactive T cells mediate protective heterologous immunity in mice. Subsets of T cell populations reactive with one epitope cross-reacted with either of several other epitopes encoded by the same or the heterologous virus. Human T cells specific to EBV-encoded BMLF1(28  ...[more]

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