Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
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ABSTRACT:
SUBMITTER: Poaty H
PROVIDER: S-EPMC3253784 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
Poaty Henriette H Coullin Philippe P Peko Jean Félix JF Dessen Philippe P Diatta Ange Lucien AL Valent Alexander A Leguern Eric E Prévot Sophie S Gombé-Mbalawa Charles C Candelier Jean-Jacques JJ Picard Jean-Yves JY Bernheim Alain A
PloS one 20120109 1
Eleven samples of DNA from choriocarcinomas were studied by high resolution CGH-array 244 K. They were studied after histopathological confirmation of the diagnosis, of the androgenic etiology and after a microsatellite marker analysis confirming the absence of contamination of tumor DNA from maternal DNA. Three cell lines, BeWo, JAR, JEG were also studied by this high resolution pangenomic technique. According to aCGH analysis, the de novo choriocarcinomas exhibited simple chromosomal rearrange ...[more]
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