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Cyclo-linopeptide B methanol tris-olvate.


ABSTRACT: The title compound, C(56)H(83)N(9)O(9)S·3CH(3)OH, is a methanol tris-olvate of the cyclo-linopeptide cyclo(Met(1)-Leu(2)-Ile(3)-Pro(4)-Pro(5)-Phe(6)-Phe(7)-Val(8)-Ile(9)) (henceforth referred to as CLP-B), which was isolated from flaxseed oil. All the amino acid residues are in an l-configuration based on the CORN rule. The cyclic nona-peptide exhibits eight trans peptide bonds and one cis peptide bond observed between the two proline residues. The conformation is stabilized by an ?-turn and two consecutive ?-turns each containing a N-H?O hydrogen bond between the carbonyl group O atom of the first residue and the amide group H atom of the fourth (?-turn) or the third residue (?-turns), repectively. In the crystal, the components of the structure are linked by N-H?O and O-H?O hydrogen bonds into chains parallel to the a axis.

SUBMITTER: Schatte G 

PROVIDER: S-EPMC3254409 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Cyclo-linopeptide B methanol tris-olvate.

Schatte Gabriele G   Labiuk Shaunivan S   Li Bonnie B   Burnett Peta-Gaye PG   Reaney Martin M   Grochulski Pawel P   Fodje Michel M   Yang Jian J   Sammynaiken Ramaswami R  

Acta crystallographica. Section E, Structure reports online 20111207 Pt 1


The title compound, C(56)H(83)N(9)O(9)S·3CH(3)OH, is a methanol tris-olvate of the cyclo-linopeptide cyclo(Met(1)-Leu(2)-Ile(3)-Pro(4)-Pro(5)-Phe(6)-Phe(7)-Val(8)-Ile(9)) (henceforth referred to as CLP-B), which was isolated from flaxseed oil. All the amino acid residues are in an l-configuration based on the CORN rule. The cyclic nona-peptide exhibits eight trans peptide bonds and one cis peptide bond observed between the two proline residues. The conformation is stabilized by an α-turn and two  ...[more]

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