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Ethyl 2-(4-hy-droxy-3-meth-oxy-phen-yl)-1-[3-(2-oxopyrrolidin-1-yl)prop-yl]-1H-benzimidazole-5-carboxyl-ate monohydrate.

ABSTRACT: In the title compound, C(24)H(27)N(3)O(5)·H(2)O, the essentially planar benzimidazole ring system [maximum deviation = 0.020?(1)?Å] forms dihedral angles of 54.10?(11) and 67.79?(6)°, respectively, with the mean plane of pyrrolidin-2-one ring and the benzene ring. The pyrrolidin-2-one ring adopts an envelope conformation with one of the methylene C atoms at the flap. An intra-molecular C-H?? inter-action is observed. In the crystal, O-H?O and O-H?N hydrogen bonds link the two components into a double-tape structure along the a axis. The crystal packing is further stabilized by weak ?-? stacking [centroid-centroid distance = 3.6632?(9)?Å] and C-H?O inter-actions.

SUBMITTER: Yoon YK

PROVIDER: S-EPMC3254439 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Ethyl 2-(4-hy-droxy-3-meth-oxy-phen-yl)-1-[3-(2-oxopyrrolidin-1-yl)prop-yl]-1H-benzimidazole-5-carboxyl-ate monohydrate.

Yoon Yeong Keng YK Ali Mohamed Ashraf MA Choon Tan Soo TS Asik Safra Izuani Jama SI Razak Ibrahim Abdul IA

Acta crystallographica. Section E, Structure reports online 20111210 Pt 1

In the title compound, C(24)H(27)N(3)O(5)·H(2)O, the essentially planar benzimidazole ring system [maximum deviation = 0.020 (1) Å] forms dihedral angles of 54.10 (11) and 67.79 (6)°, respectively, with the mean plane of pyrrolidin-2-one ring and the benzene ring. The pyrrolidin-2-one ring adopts an envelope conformation with one of the methylene C atoms at the flap. An intra-molecular C-H⋯π inter-action is observed. In the crystal, O-H⋯O and O-H⋯N hydrogen bonds link the two components into a d ...[more]

PMID: 22259586

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