Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice.

ABSTRACT:

Background

The transcription factor FoxO3a is highly expressed in brain, but little is known about the response of FoxO3a to behavioral stress and its impact in the associated behavioral changes.

Methods

We tested the response of brain FoxO3a in the learned helplessness (LH) paradigm and tested signaling pathways that mediate the response of FoxO3a.

Results

A single session of inescapable shocks (IES) in mice reduced FoxO3a phosphorylation at the Akt-regulating serine/threonine residues and induced prolonged nuclear accumulation of FoxO3a in the cerebral cortex, both indicating activation of FoxO3a in brain. The response of FoxO3a is accompanied by a transient inactivation of Akt and a prolonged activation of glycogen synthase kinase-3beta (GSK3β). Noticeably, FoxO3a

SUBMITTER: Zhou W 

PROVIDER: S-EPMC3254805 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature