Ontology highlight
ABSTRACT:
SUBMITTER: Colucci S
PROVIDER: S-EPMC3255263 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Colucci S S Brunetti G G Oranger A A Mori G G Sardone F F Specchia G G Rinaldi E E Curci P P Liso V V Passeri G G Zallone A A Rizzi R R Grano M M
Blood cancer journal 20110624 6
Wingless-type (Wnt) signaling through the secretion of Wnt inhibitors Dickkopf1, soluble frizzled-related protein-2 and -3 has a key role in the decreased osteoblast (OB) activity associated with multiple myeloma (MM) bone disease. We provide evidence that another Wnt antagonist, sclerostin, an osteocyte-expressed negative regulator of bone formation, is expressed by myeloma cells, that is, human myeloma cell lines (HMCLs) and plasma cells (CD138+ cells) obtained from the bone marrow (BM) of a l ...[more]