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Folate-decorated nanogels for targeted therapy of ovarian cancer.

ABSTRACT: Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed.

SUBMITTER: Nukolova NV

PROVIDER: S-EPMC3255291 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Folate-decorated nanogels for targeted therapy of ovarian cancer.

Nukolova Natalia V NV Oberoi Hardeep S HS Cohen Samuel M SM Kabanov Alexander V AV Bronich Tatiana K TK

Biomaterials 20110504 23

Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific ...[more]

PMID: 21536326

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