Ontology highlight
ABSTRACT:
SUBMITTER: Ding L
PROVIDER: S-EPMC3255792 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Ding Lijuan L Yuan Changji C Wei Feng F Wang Guangyi G Zhang Jing J Bellail Anita C AC Zhang Zhaobin Z Olson Jeffrey J JJ Hao Chunhai C
Cancer investigation 20110830 8
Glioblastoma-derived stem cells (GSCs) are responsible for the cancer resistance to therapies. We show here that GSC-enriched neurospheres are resistant to the treatment of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) due to the insufficient expression of the death receptor DR4 and DR5 and the overexpression of cellular Fas-associated death domain-like interleukin-1β-converting enzyme-inhibitory protein (c-FLIP). However, treatment with cisplatin leads to the upregulation of D ...[more]