The TLR4-TRIF pathway protects against H5N1 influenza virus infection.
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ABSTRACT:
SUBMITTER: Shinya K
PROVIDER: S-EPMC3255869 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
The TLR4-TRIF pathway protects against H5N1 influenza virus infection.
Shinya Kyoko K Ito Mutsumi M Makino Akiko A Tanaka Motoko M Miyake Kensuke K Eisfeld Amie J AJ Kawaoka Yoshihiro Y
Journal of virology 20111026 1
Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using mice whose TLR4-related molecules were knocked out. Microarray analysis of primary mouse lung culture cells that were LPS pretreated and infected with an H5N1 virus indicated that TLR3 mRNA was upregulated. Primary lung culture cells of TLR3 knockout mice showed no response to LPS ...[more]
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