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Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.

ABSTRACT: We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ?2 ?g/ml and micafungin minimum effective concentrations (MECs) of ?16 ?g/ml were recorded for two and one isolates, respectively.

SUBMITTER: Tashiro M

PROVIDER: S-EPMC3256053 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.

Tashiro Masato M Izumikawa Koichi K Minematsu Asuka A Hirano Katsuji K Iwanaga Naoki N Ide Shotaro S Mihara Tomo T Hosogaya Naoki N Takazono Takahiro T Morinaga Yoshitomo Y Nakamura Shigeki S Kurihara Shintaro S Imamura Yoshifumi Y Miyazaki Taiga T Nishino Tomoya T Tsukamoto Misuzu M Kakeya Hiroshi H Yamamoto Yoshihiro Y Yanagihara Katsunori K Yasuoka Akira A Tashiro Takayoshi T Kohno Shigeru S

Antimicrobial agents and chemotherapy 20111024 1

We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ≥2 μg/ml and ...[more]

PMID: 22024829

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