Ontology highlight
ABSTRACT:
SUBMITTER: Pinkhasov J
PROVIDER: S-EPMC3256590 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Pinkhasov Julia J Alvarez M Lucrecia ML Pathangey Latha B LB Tinder Teresa L TL Mason Hugh S HS Walmsley Amanda M AM Gendler Sandra J SJ Mukherjee Pinku P
Cancer immunology, immunotherapy : CII 20100908 12
Since epithelial mucin 1 (MUC1) is associated with several adenocarcinomas at the mucosal sites, it is pertinent to test the efficacy of a mucosally targeted vaccine formulation. The B subunit of the Vibrio cholerae cholera toxin (CTB) has great potential to act as a mucosal carrier for subunit vaccines. In the present study we evaluated whether a MUC1 tandem repeat (TR) peptide chemically linked to CTB would break self-antigen tolerance in the transgenic MUC1-tolerant mouse model (MUC1.Tg) thro ...[more]