Ontology highlight
ABSTRACT:
SUBMITTER: Bruscoli S
PROVIDER: S-EPMC3256913 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Bruscoli Stefano S Velardi Enrico E Di Sante Moises M Bereshchenko Oxana O Venanzi Alessandra A Coppo Maddalena M Berno Valeria V Mameli Maria Grazia MG Colella Renato R Cavaliere Antonio A Riccardi Carlo C
The Journal of biological chemistry 20111122 2
Correct function of spermatogonia is critical for the maintenance of spermatogenesis throughout life, but the cellular pathways regulating undifferentiated spermatogonia proliferation, differentiation, and survival are only partially known. We show here that long glucocorticoid-induced leucine zipper (L-GILZ) is highly expressed in spermatogonia and primary spermatocytes and controls spermatogenesis. Gilz deficiency in knock-out (gilz KO) mice leads to a complete loss of germ cell lineage within ...[more]