Unknown

Dataset Information

0

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis.


ABSTRACT: Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of systemic inflammation. Although direct inflammatory cytokine action on muscle promotes atrophy, nonmuscle sites of action for inflammatory mediators are less well described. We demonstrate that central nervous system (CNS)-delimited interleukin 1? (IL-1?) signaling alone can evoke a catabolic program in muscle, rapidly inducing atrophy. This effect is dependent on hypothalamic-pituitary-adrenal (HPA) axis activation, as CNS IL-1?-induced atrophy is abrogated by adrenalectomy. Furthermore, we identified a glucocorticoid-responsive gene expression pattern conserved in models of acute and chronic inflammatory muscle atrophy. In contrast with studies suggesting that the direct action of inflammatory cytokines on muscle is sufficient to induce catabolism, adrenalectomy also blocks the atrophy program in response to systemic inflammation, demonstrating that glucocorticoids are requisite for this process. Additionally, circulating levels of glucocorticoids equivalent to those produced under inflammatory conditions are sufficient to cause profound muscle wasting. Together, these data suggest that a significant component of inflammation-induced muscle catabolism occurs indirectly via a relay in the CNS.

SUBMITTER: Braun TP 

PROVIDER: S-EPMC3256966 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis.

Braun Theodore P TP   Zhu Xinxia X   Szumowski Marek M   Scott Gregory D GD   Grossberg Aaron J AJ   Levasseur Peter R PR   Graham Kathryn K   Khan Sheehan S   Damaraju Sambasivarao S   Colmers William F WF   Baracos Vickie E VE   Marks Daniel L DL  

The Journal of experimental medicine 20111114 12


Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of systemic inflammation. Although direct inflammatory cytokine action on muscle promotes atrophy, nonmuscle sites of action for inflammatory mediators are less well described. We demonstrate that central nervous system (CNS)-delimited interleukin 1β (IL-1β) signaling alone can evoke a catabolic program in muscle, rapidly inducing atrophy. This effect is dependent on hypothalamic-pituitary-adrenal (HPA) axis  ...[more]

Similar Datasets

| S-EPMC4677126 | biostudies-literature
| S-EPMC5563683 | biostudies-other
| S-EPMC4398592 | biostudies-literature
| S-EPMC6511471 | biostudies-literature
| S-EPMC3174533 | biostudies-literature
| S-EPMC9743740 | biostudies-literature
| S-EPMC6200183 | biostudies-literature
| S-EPMC4344321 | biostudies-literature
| S-EPMC5717018 | biostudies-literature
| S-EPMC4788520 | biostudies-literature