Ontology highlight
ABSTRACT:
SUBMITTER: Jung KC
PROVIDER: S-EPMC3256968 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20111024 12
Induction of antigen-specific T cell tolerance would aid treatment of diverse immunological disorders and help prevent allograft rejection and graft versus host disease. In this study, we establish a method of inducing antigen-specific T cell tolerance in situ in diabetic humanized mice and Rhesus monkeys receiving porcine islet xenografts. Antigen-specific T cell tolerance is induced by administration of an antibody ligating a particular epitope on ICAM-1 (intercellular adhesion molecule 1). An ...[more]