Ontology highlight
ABSTRACT:
SUBMITTER: Gupta M
PROVIDER: S-EPMC3257013 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Gupta Mamta M Hendrickson Andrea E Wahner AE Yun Seong Seok SS Han Jing Jing JJ Schneider Paula A PA Koh Brian D BD Stenson Mary J MJ Wellik Linda E LE Shing Jennifer C JC Peterson Kevin L KL Flatten Karen S KS Hess Allan D AD Smith B Douglas BD Karp Judith E JE Barr Sharon S Witzig Thomas E TE Kaufmann Scott H SH
Blood 20111111 2
The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-lived. In the present study we compared the effects of rapamycin with the dual mTORC1/mTORC2 inhibitor OSI-027 in cell lines and clinical samples representing divers lymphoid malignan ...[more]