Ontology highlight
ABSTRACT:
SUBMITTER: Stephens OW
PROVIDER: S-EPMC3257015 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Stephens Owen W OW Zhang Qing Q Qu Pingping P Zhou Yiming Y Chavan Shweta S Tian Erming E Williams David R DR Epstein Joshua J Barlogie Bart B Shaughnessy John D JD
Blood 20111109 2
IL-6 signaling can be enhanced through transsignaling by the soluble IL-6 receptor (sIL-6r), allowing for the pleiotropic cytokine to affect cells it would not ordinarily have an effect on. Serum levels of sIL-6r can be used as an independent prognostic indicator and further stratify the GEP 70-gene low-risk group to identify an intermediate-risk group in multiple myeloma (MM). By analyzing more than 600 MM patients with ELISA, genotyping, and gene expression profiling tools, we show how the com ...[more]