Ontology highlight
ABSTRACT:
SUBMITTER: Manganelli G
PROVIDER: S-EPMC3257253 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Manganelli Genesia G Fico Annalisa A Masullo Ugo U Pizzolongo Fabiana F Cimmino Amelia A Filosa Stefania S
PloS one 20120112 1
Embryonic stem (ES) cells can differentiate in vitro into a variety of cell types. Efforts to produce endodermal cell derivatives, including lung, liver and pancreas, have been met with modest success. Understanding how the endoderm originates from ES cells is the first step to generate specific cell types for therapeutic purposes. Recently, it has been demonstrated that inhibition of Myc or mTOR induces endodermal differentiation. Both Myc and mTOR are known to be activators of the Pentose Phos ...[more]