Ontology highlight
ABSTRACT:
SUBMITTER: Wang CT
PROVIDER: S-EPMC3257417 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Wang Ching-Tzu CT Chen Yi-Chun YC Wang Yi-Yun YY Huang Ming-Hao MH Yen Tzu-Li TL Li Hsun H Liang Cyong-Jhih CJ Sang Tzu-Kang TK Ciou Shih-Ci SC Yuh Chiou-Hwa CH Wang Chao-Yung CY Brummel Theodore J TJ Wang Horng-Dar HD
Aging cell 20111128 1
Aging and age-related diseases can be viewed as the result of the lifelong accumulation of stress insults. The identification of mutant strains and genes that are responsive to stress and can alter longevity profiles provides new therapeutic targets for age-related diseases. Here we reported that a Drosophila strain with reduced expression of ribose-5-phosphate isomerase (rpi), EP2456, exhibits increased resistance to oxidative stress and enhanced lifespan. In addition, the strain also displays ...[more]