Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC3257810 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Xiao Youli Y Rooker Debra D You Quincy Q Meyers Caren L Freel CL Liu Pinghua P
Chembiochem : a European journal of chemical biology 20110126 4
H(2)(18)O under the bridge: Recently, the deoxyxylulose phosphate (DXP) pathway was discovered to be a second pathway supplying isoprenoid biosynthetic precursors. One of steps is an IspG-catalyzed reductive deoxygenation of methylerythritol cyclodiphosphate (MEcPP) to 4-hydroxyl-3-methyl-2-(E)-1-diphosphate (HMBPP). Using [2-(13) C,(18) O]-MEcPP, we detected the positional isotopic exchange for the bridging oxygen in MEcPP. ...[more]