Ontology highlight
ABSTRACT:
SUBMITTER: Goulbourne CN
PROVIDER: S-EPMC3258109 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Goulbourne Chris N CN Malhas Ashraf N AN Vaux David J DJ
Journal of cell science 20111201 Pt 24
Farnesylated prelamin A accumulates when the final endoproteolytic maturation of the protein fails to occur and causes a dysmorphic nuclear phenotype; however, the morphology and mechanisms of biogenesis of these changes remain unclear. We show here that acute prelamin A accumulation after reduction in the activity of the ZMPSTE24 endoprotease by short interfering RNA knockdown, results in the generation of a complex nucleoplasmic reticulum that depends for its formation on the enzyme CTP:phosph ...[more]