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Role of Bcl-3 in solid tumors.


ABSTRACT: Bcl-3 is an established oncogene in hematologic malignancies, such as B-cell chronic lymphocytic leukemias. Nevertheless, recent research has shown that it also participates in progression of diverse solid tumors. The present review summarizes the current knowledge of Bcl3 role in solid tumors progression, including some new insights in its possible molecular mechanisms of action.

SUBMITTER: Maldonado V 

PROVIDER: S-EPMC3258214 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Role of Bcl-3 in solid tumors.

Maldonado Vilma V   Melendez-Zajgla Jorge J  

Molecular cancer 20111223


Bcl-3 is an established oncogene in hematologic malignancies, such as B-cell chronic lymphocytic leukemias. Nevertheless, recent research has shown that it also participates in progression of diverse solid tumors. The present review summarizes the current knowledge of Bcl3 role in solid tumors progression, including some new insights in its possible molecular mechanisms of action. ...[more]

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