Ontology highlight
ABSTRACT:
SUBMITTER: Bernstein DA
PROVIDER: S-EPMC3258626 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Bernstein Douglas A DA Vyas Valmik K VK Weinberg David E DE Drinnenberg Ines A IA Bartel David P DP Fink Gerald R GR
Proceedings of the National Academy of Sciences of the United States of America 20111215 2
The generation of mature functional RNAs from nascent transcripts requires the precise and coordinated action of numerous RNAs and proteins. One such protein family, the ribonuclease III (RNase III) endonucleases, includes Rnt1, which functions in fungal ribosome and spliceosome biogenesis, and Dicer, which generates the siRNAs of the RNAi pathway. The recent discovery of small RNAs in Candida albicans led us to investigate the function of C. albicans Dicer (CaDcr1). CaDcr1 is capable of generat ...[more]